Prinsip dan Aplikasi Hewan Model dalam Penelitian Kanker

Authors

Kusmardi
Universitas Indonesia
Bambang Priosoeryanto
IPB University image/svg+xml
Rahayu Wiranti
IPB University image/svg+xml

Keywords:

Prinsip, Aplikasi Hewan Model, Penelitian Kanker

Synopsis

Pengembangan terapi antikanker yang efektif dan aman merupakan salah satu tantangan terbesar dalam dunia medis modern. Kemajuan fundamental dalam bidang ini sangat bergantung pada penggunaan model praklinis yang mampu mereplikasi kompleksitas biologi tumor manusia secara akurat. Buku ajar ini disusun untuk mengisi celah penting dalam literatur ilmiah berbahasa Indonesia, dengan menyajikan panduan komprehensif mengenai penggunaan hewan model non-rekayasa genetika (Non-GMO) dalam penelitian onkologi. Fokus utama buku ini adalah pada model-model yang diinduksi secara kimiawi atau melalui transplantasi, yang sering kali menawarkan keunggulan dalam meniru heterogenitas dan progresi sporadis kanker pada manusia. Urgensi pemahaman mendalam terhadap model-model ini semakin meningkat seiring dengan kesadaran akan pentingnya validitas eksternal dan relevansi klinis dari sebuah penelitian. Tujuan penulisan buku ini adalah untuk membekali para mahasiswa, peneliti, dan akademisi dengan pengetahuan teoretis dan praktis yang kokoh, mulai dari filosofi pemilihan model, standardisasi prosedur, hingga analisis hasil yang valid dan etis.

Chapters

  • PRAKATA
  • KATA PENGANTAR
  • DAFTAR ISI
  • Bab 1 FILOSOFI DAN JUSTIFIKASI PENGGUNAAN HEWAN MODEL
  • Bab 2 STANDAR LINGKUNGAN DAN NUTRISI UNTUK HEWAN MODEL KANKER
  • Bab 3 UJI TOKSISITAS BAHAN ALAM UNTUK RISET ANTIKANKER
  • Bab 4 RUTE PEMBERIAN KANDIDAT OBAT ANTIKANKER
  • Bab 5 MONITORING TUMOR
  • Bab 6 PROSEDUR NEKROPSI DAN PENGAMBILAN SAMPEL BIOLOGIS
  • Bab 7 MODEL KANKER PAYUDARA
  • Bab 8 MODEL KANKER KOLOREKTAL
  • Bab 9 MODEL KANKER KULIT
  • Bab 10 MODEL KANKER PROSTAT
  • Bab 11 MODEL KANKER DARAH DAN KELENJAR GETAH BENING (LEUKEMIA & LYMPHOMA)
  • Bab 12 ANALISIS EFEK ANTIKANKER PADA HEWAN MODEL KANKER
  • Bab 13 PEMBACAAN SEDIAAN IMUNOHISTOKIMIA MENGGUNAKAN SOFTWARE
  • Bab 14 ETIKA PENELITIAN DAN PENYUSUNAN DOKUMEN KAJI ETIK (ETHICAL CLEARANCE)
  • REFERENSI
  • GLOSARIUM
  • PROFIL PENULIS

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Author Biographies

Kusmardi, Universitas Indonesia

Prof. Dr. Drs. H. Kusmardi, M.Sc., CIRR adalah Guru Besar Tetap di Fakultas Kedokteran, Universitas Indonesia. Sekarang adalah mahasiswa Program Studi Doktor Ilmu Dakwah di Fakultas Ilmu Agama Islam, Universitas Islam Asy-Syafi’iyah Jakarta. Pendidikan Doktor sebelumnya ditempuh di Program Doktor Ilmu Biomedik FKUI Jakarta dan Program Doktor Ilmu Biomedis Hewan IPB Bogor. Program Magister di FKUI, Program S1 di Biologi FMIPA UI. Pernah Belajar Biologi Molekular di Melborne University. SD sampai SMA di kota kelahirannya, Sumenep, Madura. Bidang penelitian utamanya meliputi kanker kolorektal dan kanker payudara, dengan penekanan khusus pada eksplorasi potensi efek penghambatan berbagai obat alami Indonesia terhadap karsinogenesis pada kedua jenis kanker tersebut. Penelitiannya juga melibatkan identifikasi jaringan normal versus perkembangan kanker menggunakan penanda molekuler dan model komputasional. Selain itu, ia telah menulis beberapa buku, diantaranya: The Mouse Model for Breast Cancer; The Mouse Model for Colorectal Cancer; Lunasin: A Soybean Polypeptide as a Chemopreventive Adjuvant for Colon Cancer; Pembuatan Antibodi Poliklonal, Peristiwa Ilmiah yang telah Dijelaskan dalam Al-Qur’an, Manusia dan Semesta yang telah Dijelaskan dalam Al-Qur’an, Pemilihan Uji Statistik Kedokteran, Desain Penelitian Kedokteran dan Kesehatan, Pulasan Imunoflouresensi dan Aplikasinya, dan Filsafat untuk Calon Doktor Rumpun Ilmu Kesehatan. Selama ini beliau sudah menghasilkan seratus lebih publikasi internasional bereputasi terindeks Scopus, puluhan hak kekayaan intelektual. Saat ini Prof. Kusmardi menjadi dosen home base di Program Studi Doktor Ilmu Biomedik FKUI, selain dosen tetap di Prodi Magister Ilmu Biomedik, Prodi Dokter Spesialis Patologi Anatomik, dan Prodi Pendidikan Dokter FKUI. Beliau secara aktif menjadi Reviewer internal hibah UI dan Reviewer Nasional Proposal Hibah Kemendiktisaintek, Auditor Internal Akademik UI, PIC QA Drug Development Research Center IMERI FKUI, Cancer drug discovery coordinator di Human Cancer Research Center IMERI FKUI, tim penjamin mutu akademik Program Doktor Ilmu Kedokteran FKUI, serta sebagai Asesor LAM-PTKes divisi Kedokteran. Untuk mempertajam khasanah pengetahuannya, beliau juga menjadi Ketua Dewan Redaksi Majalah Patologi Indonesia, serta aktif menjadi reviewer tetap pada beberapa jurnal internasional terindeks scopus Q1. Kemampuan mengenalkan statistik diperoleh sejak mengajar statistic di prodi S1, Spesialis, dan S3 sejak lama.

Bambang Priosoeryanto, IPB University

Prof. drh. Bambang Pontjo Priosoeryanto, M.S., Ph.D., APVet., DACCM adalah Guru Besar di bidang Patologi Veteriner pada Sekolah Kedokteran Hewan dan Biomedis (SKHB) IPB University.  Beliau dikenal sebagai akademisi, peneliti, dan praktisi veteriner dengan kepakaran utama dalam patologi veteriner, patologi tumor, neuropatologi, diagnostik patologi, kultur sel dan jaringan, serta pengembangan herbal medicine veteriner. Beliau menyelesaikan pendidikan dokter hewan dan magister di IPB, kemudian meraih gelar Ph.D. di bidang Pathology and Preventive Veterinary Medicine dari United Graduate School of Veterinary Sciences Yamaguchi University, Jepang. Prof. Bambang adalah salah seorang pemegang Diplomate Asian College of Conservation Medicine dan Brevet Ahli Patologi Veteriner Indonesia. Selain itu, Prof. Bambang juga memiliki pengalaman postdoctoral di bidang neuropatologi, termasuk riset terkait penyakit prion di Georg-August University Göttingen, Jerman. Dalam karier akademiknya, saat ini Prof. Bambang menjabat sebagai Kepala Divisi Patologi Veteriner serta Ketua Program Studi Magister Ilmu Biomedis Hewan di SKHB IPB. Sejak 2016 hingga saat ini sebagai Guest Professor pada University of Miyazaki, Jepang, dan pada 2016–2019 di Faculty of Veterinary Science Royal University of Agriculture, Cambodia.  Minat dan kontribusi ilmiah beliau meliputi patologi penyakit degeneratif, tumor pada hewan, penyakit zoonotik, biosecurity, animal welfare, penggunaan hewan coba dalam penelitian biomedis, serta pengembangan kapasitas pendidikan kedokteran hewan di tingkat nasional dan internasional. Hingga saat ini Prof. Bambang sudah menulis lebih dari 100 makalah ilmiah yang dipublikasikan pada jurnal ilmiah nasional dan internasional serta makalah seminar pada berbagai seminar ilmiah nasional maupun internasional. Beliau sudah meneliti sebanyak 56 judul penelitian dengan 26 judul sebagai Principal Investigator/PI dengan mendapatkan dana hibah dari dalam dan luar negeri seperti Jepang, Jerman, Thailand, Amerika, Korea, Taiwan, Australia, dll, serta memiliki 8 paten. Sebagai pendidik, Prof. Bambang sudah meluluskan lebih dari 392 mahasiswa dari berbagai strata, bidang ilmu dan perguruan tinggi, mulai dari S1, S2, S3, Profesi Dokter Hewan, Spesialis dan Subspesialis. Di tingkat nasional, beliau sangat aktif dalam organisasi profesi kedokteran hewan, menjabat sebagai salah satu ketua pada Pengurus Besar Perhimpunan Dokter Hewan Indonesia (PB PDHI) tahun 2010-2018, menjabat sebagai Ketua Cabang Bogor hingga Ketua Pengurus Pusat Perkumpulan Pemberantasan Penyakit Parasitik Indonesia (P4I) tahun 1996-2008, dan Ketua Umum Asosiasi Patologi Veteriner Indonesia (APVI) tahun 2008-2017. Prof. Bambang juga aktif dalam organisasi profesi veteriner global, sebagai President Asian Society of Veterinary Pathology (ASVP) pada tahun 2009-2011. Pada tahun 2020-2022 beliau adalah orang Indonesia pertama yang duduk sebagai councilor pada World Veterinary Association (WVA) yang berkedudukan di Brussel, Belgia. Saat ini Prof. Bambang menjabat sebagai Ketua IV yang membawahkan kluster Kesehatan pada Forum Organisasi Profesi IPTEKS Indonesia (FOPI). Sejak 2018 hingga saat ini, Prof. Bambang menjabat sebagai Sekretaris Jenderal Federation of Asian Veterinary Associations (FAVA) yang berkedudukan di Bangkok, Thailand dan Fukuoka, Jepang. Dengan pengalaman panjang di dunia akademik, penelitian, dan organisasi profesi, Prof. Bambang berkontribusi aktif dalam penguatan dan pengembangan ilmu kedokteran hewan dan biomedis di Indonesia maupun Asia.

Rahayu Wiranti, IPB University

Dr. drh. Rahayu Woro Wiranti adalah Dosen di Divisi Patologi Veteriner, Sekolah Kedokteran Hewan dan Biomedis (SKHB), IPB University. Beliau dikenal sebagai akademisi dan peneliti dengan kepakaran utama di bidang patologi veteriner, khususnya patologi komparatif dan patologi hewan satwa liar. Beliau menyelesaikan pendidikan dokter hewan di Fakultas Kedokteran Hewan IPB pada tahun 2015 dan di tahun yang sama juga mendapatkan beasiswa Program Magister dan Doktor untuk Sarjana Unggul (PMDSU) Batch 2 dari Kementerian Pendidikan Tinggi, Sains dan Teknologi Republik Indonesia untuk pendidikan Doktoralnya tanpa mengambil Magister. Selama menempuh pendidikan Doktoral, Dr Woro mendapat kesempatan internship di Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University Japan. Dr Woro juga mendapatkan Post Doctoral dari IPB pada tahun 2021. Kontribusi ilmiah Dr Woro diawali dengan penelitian potensi penularan penyakit zoonotik (virus dan cendawan) asal kelelawar buah di wilayah Indonesia. Penelitian tersebut menjadi topik skripsi hingga disertasi dan tetap dilanjutkan menjadi riset utama saat ini selain juga melakukan penelitian pada babi hutan, babi domestik, satwa akuatik, dan hewan laboratorium. Dr Woro aktif melakukan penelitian terkait kedokteran hewan dan biomedis serta aktif dalam kegiatan diagnostik patologi dari kasus-kasus lapang terkait patologi veteriner dan sitopatologi. Dr Woro merupakan anggota aktif dari Asosiasi Patologi Veteriner Indonesia (APVI).

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Prinsip dan Aplikasi Hewan Model dalam Penelitian Kanker

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Copyright (c) 2026 Prof. Dr. Drs. H. Kusmardi, M.Sc., CIRR, Prof. drh. Bambang Pontjo Priosoeryanto, M.S., Ph.D., APVet., DACCM, Dr. drh. Rahayu Woro Wiranti (Author)

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Prinsip dan Aplikasi Hewan Model dalam Penelitian Kanker. (2026). Library Buku Penerbit KBM. https://librarypenerbitkbm.science/index.php/buku/catalog/book/1333