SCAFFOLD BERBASIS TUMBUHAN: Metode Deselulerisasi dan Aplikasinya dalam Kedokteran Gigi

Authors

Martha Mozartha
Sriwijaya University image/svg+xml
Zen Hafy
Sriwijaya University image/svg+xml
Lisa Amir
Universitas Indonesia
Evi Lusiana
Universitas Sriwijaya

Keywords:

SCAFFOLD, TUMBUHAN, Deselulerisasi

Synopsis

Scaffold berbasis tumbuhan merupakan pendekatan inovatif yang menawarkan alternatif biomaterial yang berkelanjutan, biokompatibel, serta memiliki potensi besar untuk dikembangkan melalui berbagai strategi modifikasi. Buku berjudul Scaffold Berbasis Tumbuhan: Metode Deselulerisasi dan Aplikasinya dalam Kedokteran Gigi ini disusun sebagai upaya untuk merangkum dan mengkaji perkembangan ilmu pengetahuan mengenai pemanfaatan biomaterial berbasis tumbuhan dalam rekayasa jaringan tulang, khususnya pada bidang kedokteran gigi. Pembahasan dalam monograf ini mencakup konsep dasar scaffold tumbuhan, perkembangan riset scaffold yang berasal dari tumbuhan, metode deselulerisasi, tantangan yang dihadapi, serta peluang penelitian masa depan. Hadirnya buku ini dapat menjadi landasan teoretis, pemantik diskusi, sekaligus referensi awal bagi rekan-rekan klinisi, peneliti, dan mahasiswa yang tertarik pada pengembangan biomaterial berbasis bahan alam.

Chapters

  • KATA PENGANTAR
  • DAFTAR ISI
  • DAFTAR GAMBAR
  • DAFTAR TABEL
  • BAB 1 PENDAHULUAN
  • BAB 2 KONSEP DASAR REKAYASA JARINGAN TULANG
  • BAB 3 SCAFFOLD BERBASIS TUMBUHAN: PERKEMBANGAN DAN POTENSI
  • BAB 4 KESENJANGAN RISET DAN ARAH PENGEMBANGAN MASA DEPAN
  • BAB 5 KESIMPULAN
  • DAFTAR PUSTAKA
  • PROFIL PENULIS

Downloads

Download data is not yet available.

Author Biographies

Martha Mozartha, Sriwijaya University

drg. Martha Mozartha, M.Si., Menyelesaikan pendidikan Sarjana Kedokteran Gigi pada tahun 2003 dan meraih gelar Dokter Gigi dari Fakultas Kedokteran Gigi Universitas Indonesia pada tahun 2005. Melanjutkan pendidikan S2 pada program Ilmu Kedokteran Gigi Dasar di Universitas Indonesia dan lulus pada tahun 2010. Saat ini aktif sebagai pengajar di Departemen Material Kedokteran Gigi, Program Studi Kedokteran Gigi, Fakultas Kedokteran Universitas Sriwijaya. Beliau juga aktif sebagai penerjemah dan kontributor buku kedokteran gigi, di antaranya buku Craig’s Restorative Dental Material 14th (Elsevier) dan Anatomi Kedokteran Gigi: Aplikasi Praktik Klinis (EGC).

Zen Hafy, Sriwijaya University

Dr. dr. Zen Hafy, M.Biomed., Menyelesaikan pendidikan dokter di Universitas Sriwijaya pada tahun 1996. Beliau kemudian melanjutkan pendidikan jenjang Magister (S2) dan Doktoral (S3) pada program studi Ilmu Biomedik di Universitas Indonesia, yang masing-masing diselesaikan pada tahun 2002 dan 2008. Beliau telah mengabdi sebagai dosen di Fakultas Kedokteran Universitas Sriwijaya sejak tahun 1998. Beliau menjabat sebagai Kepala Program Studi Magister Ilmu Biomedik di Fakultas Kedokteran Universitas Sriwijaya tahun 2017 -2025 dan turut berkontribusi secara global sebagai Director of Medical Operations di FHI Clinical sejak tahun 2022.

Lisa Amir, Universitas Indonesia

Prof. drg. Lisa R. Amir, Ph.D., Menyelesaikan pendidikan dokter gigi di Fakultas Kedokteran Gigi Universitas Indonesia pada tahun 1999. Melanjutkan pendidikan tingkat doktoral (Ph.D) di Academic Center for Dentistry Amsterdam (ACTA), Vrije Universiteit, Belanda, dan lulus pada tahun 2007. Memulai karir mengajar sebagai dosen di Departemen Biologi Oral Universitas Indonesia sejak tahun 2009. Saat ini, beliau menjabat sebagai Dekan Fakultas Kedokteran Gigi Universitas Indonesia sejak tahun 2025. Beliau aktif menulis artikel ilmiah serta buku, di antaranya Potensi Pemulihan Tulang Rahang Melalui Rekayasa Jaringan; Transformasi Pendekatan Kedokteran Gigi Regeneratif.

Evi Lusiana, Universitas Sriwijaya

Dr. dr. Evi Lusiana, M.Biomed., Menyelesaikan pendidikan S1 Kedokteran di Fakultas Kedokteran Universitas Sriwijaya pada tahun 2006. Melanjutkan pendidikan S2 Ilmu Biomedis di institusi yang sama dan lulus pada tahun 2017. Pendidikan doktoral (S3) Ilmu Biomedis juga diselesaikan di Fakultas Kedokteran Universitas Sriwijaya pada tahun 2022. Pada tahun yang sama, beliau turut mengikuti program CBCD Trainee di Rutgers University. Saat ini, beliau berdedikasi di institusinya sebagai pengajar pada Departemen Farmakologi, Fakultas Kedokteran Universitas Sriwijaya.

References

Ramalingam, Sundar & Sundar, Chalini & Jansen, John & Alghamdi, Hamdan. (2020). Alveolar bone science: Structural characteristics and pathological changes. 10.1016/B978-0-08-102478-2.00001-5.

Jonasson G, Skoglund I, Rythén M. The rise and fall of the alveolar process: Dependency of teeth and metabolic aspects. Arch Oral Biol. 2018 Dec;96:195-200. doi: 10.1016/j.archoralbio. 2018.09.016.

Li T, Zeng X, Zou S, Xu Y, Duan P. Recent advances in horizontal alveolar bone regeneration. Biomed Mater. 2023 Jul 24;18(5). doi: 10.1088/1748-605X/acd672.

Poernomo H. Teknik bone tissue engineering (BTE) untuk regenerasi jaringan periodontal dan estetik pada edentulous ridge. Interdental Jurnal Kedokteran Gigi (IJKG). 2019 Dec 27;15(2).

Saberian E, Jenča A, Zafari Y, Jenča A, Petrášová A, Zare-Zardini H, Jenčová J. Scaffold Application for Bone Regeneration with Stem Cells in Dentistry: Literature Review. Cells. 2024 Jun 19;13(12):1065. doi: 10.3390/cells13121065.

Granito RN, Custódio MR, Rennó ACM. Natural marine sponges for bone tissue engineering: The state of art and future perspectives. J Biomed Mater Res B Appl Biomater. 2017 Aug;105(6):1717-1727. doi: 10.1002/jbm.b.33706.

Huang X, Lou Y, Duan Y, Liu H, Tian J, Shen Y, Wei X. Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances. Bioact Mater. 2023 Nov 10;33:129-156. doi: 10.1016/j.bioactmat. 2023.10.031

Wong ML, Griffiths LG. Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization. Acta Biomater. 2014 May;10(5):1806–16. doi:10.1016/j.actbio. 2014.01.028.

Predeina, A. L., Dukhinova, M. S., & Vinogradov, V. V. (2020). Bioreactivity of decellularized animal, plant, and fungal scaffolds: perspectives for medical applications. Journal of Materials Chemistry B. doi:10.1039/d0tb01751e

Modulevsky, D. J.; Lefebvre, C.; Haase, K.; Al-Rekabi, Z.; Pelling, A. E. Apple derived cellulose scaffolds for 3D mammalian cell culture. PLoS One 2014, 9 (5), No. e97835.

Nugraha, I. S., Alamsyah, A., & Sahuri, S. (2018). Komoditi gambir sebagai tanaman sela diantara karet untuk peningkatan pendapatan petani karet (studi kasus : Desa Toman, Sumatera Selatan). Warta Perkaretan, 37(2), 107–118 doi: 10.22302/ppk.wp.v37i2.600

Hilmi HL, Rahayu D. Aktivitas farmakologi gambir (Uncariagambir Roxb.). Farmaka. 2018;16(2):134-41

Sakti AS, Saputri FC, Mun’im A. Microscopic Characters, Phytochemical Screening Focus on Alkaloid and Total Phenolic Content of biokompatibelity Roxb. and Uncaria sclerophylla Roxb. Leaves. Pharmacog J. 2019;11(1):119-23. Doi: 10.5530/pj.2019.1.20

Esmaeili J, Jadbabaee S, Mohebi Far F, Esmaeilpour Lukolayeh M, Kırboğa KK, Rezaei FS, et al. Decellularized Alstroemeria flower stem modified with chitosan for tissue engineering purposes: A cellulose/chitosan scaffold. Int J Biol Macromol. 2022 Apr 1;204:321-332. doi: 10.1016/j.ijbiomac.2022.02.019.

Smith BT, Shum J, Wong ME, Mikos AG, Young S. Bone tissue engineering challenges in oral & maxillofacial surgery. Adv Exp Med Biol. 2015;881:57–78. doi:10.1007/978-3-319-22345-2_4

Qu H, Fu H, Han Z, Sun Y. Biomaterials for bone tissue engineering scaffolds: a review. RSC Adv. 2019;9:26252–62. doi:10.1039/C9RA05214C.

Velasco MA, Narváez-Tovar CA, Garzón-Alvarado DA. Design, materials, and mechanobiology of biodegradable scaffolds for bone tissue engineering. Biomed Res Int. 2015;2015:729076. doi:10.1155/2015/729076.

Murphy CM, O’Brien FJ, Little DG, Schindeler A. Cell-scaffold interactions in the bone tissue engineering triad. Eur Cell Mater. 2013;26:120-132.

Jiao M, Shuai T, Zhao Z, Wu Y, Yu L, Sun J, De Caro R, Macchi V, Porzionato A, Stocco E, Jin C. Categories, applications, and potential of stem cells in bone regeneration: an overview. Front Med. 2025;12:1606100. doi:10.3389/fmed.2025.1606100.

Vater C, Männel C, Bolte J, Tian X, Goodman S, Zwingenberger S. Effectiveness of dental pulp-derived stem cells and bone marrow derived mesenchymal stromal cells implanted into a murine critical bone defect. Curr Stem Cell Res Ther. (2022) 17:480–91. doi: 10.2174/1574888X176662202 15100732

Zhang Y, Xing Y, Jia L, Ji Y, Zhao B, Wen Y, dkk An in vitro comparative study of multisource derived human mesenchymal stem cells for bone tissue engineering. Stem Cells Dev. (2018) 27:1634–45. doi: 10.1089/scd.2018.0119

Kargozar S, Mozafari M, Hamzehlou S, Brouki Milan P, Kim HW, Baino F. Bone tissue engineering using human cells: a comprehensive review on recent trends, current prospects, and recommendations. Appl Sci. 2019;9(1):174. doi:10.3390/app9010174

Basyuni S, Farook SA, Khan MM, Deb S, Brocklebank L, McLean C, et al. Systematic scoping review of mandibular bone tissue engineering. Br J Oral Maxillofac Surg. 2020;58:632–42. doi:10.1016/j.bjoms.2020.03.016.

Valentino A, Di Cristo F, Bosetti M, Amaghnouje A, Bousta D, Conte R, et al. Bioactivity and delivery strategies of phytochemical compounds in bone tissue regeneration. Appl Sci. 2021;11(11):5122. doi: 10.3390/app11115122.

Oliveira ER, Nie L, Podstawczyk D, Allahbakhsh A, Ratnayake J, Brasil DL, Shavandi A. Advances in growth factor delivery for bone tissue engineering. Int J Mol Sci. 2021;22(2):903. doi:10.3390/ijms22020903.

Yang D, Xiao J, Wang B, Li L, Kong X, Liao J. The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109927. doi: 10.1016/j.msec.2019.109927.

Fadhlallah, P.M., Yuliati, A., Soesilawati, P., & Pitaloka, P. (2018). Biodegradation and Compressive Strength Test of Scaffold with Different Ratio as Bone Tissue Engineering Biomaterial.

De Witte, T.-M., Fratila-Apachitei, L.E.,Zadpoor, A.A., and Peppas, N.A. (2018). Bone tissue engineering via growth factor delivery: From scaffolds to complex matrices. Regen.Biomater. 5, 197–211. https://doi.org/10.1093/rb/ rby013

Lee SS, Du X, Kim I, Ferguson SJ. Scaffolds for bone-tissue engineering. Matter. 2022;5(9):2722–59. doi:10.1016/j. matt.2022.07.006.

Chen, G., Dong, C., Yang, L., and Lv, Y. (2015). 3D scaffolds with different stiffness but the same microstructure for bone tissue engineering. ACS Appl. Mater. Interfaces 7, 15790–15802. https://doi.org/10.1021/acsami.5b02662

Kim, C.-S., Kim, J.-H., Kim, B., Park, Y.-S., Kim, H.-K., Tran, H.T., Kim, S.H., Jeon, H., Kim, S., Sim, J.H., dkk (2017). A specific groove pattern can effectively induce osteoblast differentiation. Adv. Funct. Mater. 27, 1703569.

Dalby, M.J., Gadegaard, N., Tare, R., Andar, A., Riehle, M.O., Herzyk, P., Wilkinson, C.D.W., and Oreffo, R.O.C. (2007). The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nat. Mater. 6, 997–1003. https://doi.org/10.1038/ nmat2013

Marian D, Toro G, D’Amico G, Trotta MC, D’Amico M, Petre A, dkk Challenges and innovations in alveolar bone regeneration: a narrative review on materials, techniques, clinical outcomes, and future directions. Medicina (Kaunas). 2025;61(1):20. doi:10.3390/medicina61010020.

Santos MS, Silva JC, Carvalho MS. Hierarchical biomaterial scaffolds for periodontal tissue engineering: recent progress and current challenges. Int J Mol Sci. 2024;25(16):8562. doi:10.3390/ijms25168562.

Ramadoss R, Das R, Viola EA, Padmanabhan R, Ramani P. Mechanotransduction and alveolar bone remodelling: a narrative review of dynamics and mechanisms. Chin J Dent Res. 2025;28(4):241–251. doi:10.3290/j.cjdr. b6745523

Asa’ad F, Pagni G, Pilipchuk SP, Giannì AB, Giannobile WV, Rasperini G. 3D-printed scaffolds and biomaterials: review of alveolar bone augmentation and periodontal regeneration applications. Int J Dent. 2016;2016:1239842. doi:10.1155/2016/ 1239842.

Premjit Y, Lawrence M, Goyal A, Ferreira C, Jones EA, Ganguly P. Biomimetic three-dimensional (3D) scaffolds from sustainable biomaterials: innovative green medicine approach to bone regeneration. J Funct Biomater. 2025;16:238. doi:10.3390/jfb16070238.

Contessi Negrini N, Toffoletto N, Farè S, Altomare L. Plant tissues as 3D natural scaffolds for adipose, bone and tendon tissue regeneration. Front Bioeng Biotechnol. 2020;8:723. doi: 10.3389/fbioe.2020.00723.

Rabbani M, Salehani AA, Farnaghi M, Moshtaghi M. Plant decellularization by chemical and physical methods for regenerative medicine: a review article. J Med Signals Sens. 2024 Apr;14(4):10. doi:10.4103/jmss.jmss_20_22.

Hasan MM, Swapon AR, Dipti TI, Choi YJ, Yi HG. Plant-based decellularization: a novel approach for perfusion-compatible tissue engineering structures. J Microbiol Biotechnol. 2024;34(5):1003-1016.

Lee J, Jung H, Park N, Park SH, Ju JH. Induced osteogenesis in plants decellularized scaffolds. Sci Rep. 2019 Dec 27;9(1):20194. doi: 10.1038/s41598-019-56651-0

Walawalkar S, Almelkar S. Fabricating a pre-vascularized large-sized metabolically-supportive scaffold using Brassica oleracea leaf. Journal of Biomaterials Applications. 2021;36(1):140-153. doi:10.1177/0885328220968388

Harris AF, Lacombe J, Zenhausern F. The emerging role of decellularized plant-based scaffolds as a new biomaterial. Int J Mol Sci. 2021;22:12347. doi:10.3390/ijms222212347.

Vargas-Ovalle MI, Demitri C, Madaghiele M. Plant-based scaffolds for tissue engineering: a review. Polymers. 2025;17:2705. doi:10.3390/polym17192705.

Gershlak JR, Hernandez S, Fontana G, Perreault LR, Hansen KJ, Larson SA, Binder BY, Dolivo DM, Yang T, Dominko T, Rolle MW, Weathers PJ, Medina-Bolivar F, Cramer CL, Murphy WL, Gaudette GR. Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds. Biomaterials. 2017 May;125:13-22 doi: 10.1016/j.biomaterials.2017.02.011

Hasanzadeh, Ahmad & Alipour, Atefeh & Ghasemi, Sajedeh & Hosseini, Sadi & Farrokhi, Naser & Wang, Peng-Yuan & Zarrabi, Ali & Mohammadi, Javad & Shahsavarani, Hosein. (2024). Proanthocyanidin-Imbued Cellulosic 3-Dimentional Intrinsic Aligned Nanostructures: A Novel Approach for Dental and Bone Regeneration using Dental Pulp Derived Stem Cells. Journal of Science Advanced Materials and Devices. 9. 10.1016/j.jsamd.2024.100820.

Toker-Bayraktar M, Ertugrul Mİ, Odabas S, Garipcan B. A typical method for decellularization of plants as biomaterials. MethodsX. 2023 Sep 17;11:102385. doi: 10.1016/j.mex.2023. 102385

Lacombe J, Harris AF, Zenhausern R, Karsunsky S, Zenhausern F. Plant-based scaffolds modify cellular response to drug and radiation exposure compared to standard cell culture models. Frontiers in bioengineering and biotechnology. 2020 Aug 7;8:932

Mahendiran B, Muthusamy S, Sampath S, Jaisankar SN, Selvakumar R, Krishnakumar GS. In vitro and in vivo biocompatibility of decellularized cellulose scaffolds functionalized with kitosan and platelet rich plasma for tissue engineering applications. Int J Biol Macromol. 2022 Sep 30;217:522-535. doi: 10.1016/j.ijbiomac.2022. 07.052.

Munira, Trioktafiani G, Nasir M. Uji aktivitas antibakteri kombinasi ekstrak daun sirih dan biji pinang serta gambir terhadap Streptococcus mutans. J Ilm Ibnu Sina. 2020 Okt;5(2):298-308. doi: 10.36387/jiis.v5i2.501.

Melati, Parbuntari H. Screening fitokimia awal (analisis qualitative) pada daun gambir (Uncaria gambir Roxb) asal Siguntur Muda. Periodic. 2022;11(3):88-92

Munggari, I.P.; Kurnia, D.; Deawati, Y.; Julaeha, E. Current Research of Phytochemical, Medicinal and Non-Medicinal Uses of Uncaria gambir Roxb.: A Review. Molecules 2022, 27, 6551. https://doi.org/10.3390/ molecules27196551

Rosalina L, Amran R, Yuliana, Surya Mentari TA, Oktarina R, Fadillah R. Bioactive compound composition in tea varieties and gambir for biomedical potential. Health Leadersh Qual Life [Internet]. 2025 Sep 10 ;4:761

Lin SY, Kan JY, Lu CC, Huang HH, Cheng TL, Huang HT, et al. Green tea catechin (-)-epigallocatechin-3-gallate (EGCG) facilitates fracture healing. Biomolecules. 2020 Apr 17;10(4):620. doi: 10.3390/biom10040620.

Palma-Lara I, Calzada-Mendoza CC, Mera-Jiménez E, Romero López E, Amaya-Espinoza JL, Parra-Barrera A, et al. Phytochemical properties of (-)-epicatechin promotes bone regeneration inducing osteogenic markers expression BMP2, SPARC, and RUNX2 in mesenchymal stem cells in vitro. J Med Food. 2025 Aug;28(8):757-767. doi: 10.1089/jmf.2024.0125

Rahmaddiansyah R, Rahmi W, Rita RS. Anti-inflammatory effect of gambier catechin (Uncaria gambir Roxb) on rheumatoid arthritis: a review. SEE J Immunol. 2023 Oct 21;6(1):92-97. doi: 10.3889/seejim.2023.6055.

Li H, Zhang Z, Liu J, Wang H. Antioxidant scaffolds for enhanced bone regeneration: recent advances and challenges. BioMed Eng OnLine. 2025;24:41. doi: 10.1186/s12938-025-01370-z.

Putra A, Nugraha BA, Amran A. Synthesis and characterization of hydrogel composite based on bacterial cellulose-gambir leaf extract (Uncaria gambir Roxb.). J Phys Conf Ser. 2018;1040(1):012014. doi: 10.1088/1742-6596/1040/1/012014

Shang L, Wang S, Mao Y. Recent advances in plant-derived polysaccharide scaffolds in tissue engineering: A review. Int J Biol Macromol. 2024 Oct;277(Pt 1):133830. doi: 10.1016/j.ijbiomac.2024.133830.

S H Aswathy, Mohan CC, P S U, Krishnan AG, Nair MB. Decellularization and oxidation process of bamboo stem enhance biodegradation and osteogenic differentiation. Mater Sci Eng C Mater Biol Appl. 2021 Feb;119:111500. doi: 10.1016/j.msec.2020.111500.

Mahendiran B, Muthusamy S, Janani G, Mandal BB, Rajendran S, Krishnakumar GS. Surface modification of decellularized natural cellulose scaffolds with organosilanes for bone tissue regeneration. ACS Biomater Sci Eng. 2022;8:2000-2015.

Zhu Y, Zhang Q, Wang S, Zhang J, Fan S, Lin X. Current advances in the development of decellularized plant extracellular matrix. Front Bioeng Biotechnol. 2021;9:712262. doi:10.3389/fbioe. 2021.712262.

Yun J, Cho M, Culver M, Pearce DP, Kim C, Witzenburg CM, et al. Characterization of decellularized plant leaf as an emerging biomaterial platform. ACS Biomater Sci Eng. 2024 Oct 14;10(10):6144-6154. doi: 10.1021/acsbiomaterials.4c01254.

Kasravi M, Ahmadi A, Babajani A, Niknejad H. Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine. Biomater Res. 2023 Feb 21;27(1):10. doi: 10.1186/s40824-023-00348-z.

SCAFFOLD BERBASIS TUMBUHAN: Metode Deselulerisasi dan Aplikasinya dalam Kedokteran Gigi

Published

April 16, 2026

Details about the available publication format: PREVIEW

PREVIEW

ISBN-13 (15)

978-634-278-293-4

Physical Dimensions

How to Cite

SCAFFOLD BERBASIS TUMBUHAN: Metode Deselulerisasi dan Aplikasinya dalam Kedokteran Gigi. (2026). Library Buku Penerbit KBM. https://librarypenerbitkbm.science/index.php/buku/catalog/book/1215